david stevens archaeologist

An HKY dose of 1.2 10(8) given 4 times prolonged survival (P = 0.02), but showed dose-limiting toxicity. In this symposium, the most important fungal pathogens that cause infections in humans, particularly in immunocompromised patients, are considered, with emphasis on how recent experimental work may lead to a better understanding of the role of cytokines and their use in therapy. Oral itraconazole is attractive for continuing therapy in the patient who responds to initial iv therapy (CIII). View details for Web of Science ID 000175665800009. Stevens, D. A., White, T. C., Perlin, D. S., Selitrennikoff, C. P. Advances against aspergillosis (September 9-11, 2004, San Francisco, California). Here, we compared ABLC and AmBi directly in a coccidioidal meningitis model. Denning, D. W., Stepan, D. E., Blume, K. G., Stevens, D. A. ULCERATIVE TRACHEOBRONCHITIS AFTER LUNG TRANSPLANTATION - A NEW FORM OF INVASIVE ASPERGILLOSIS. We compared various amphotericin B formulations (no treatment or 0.8 mg of Fungizone [conventional deoxycholate amphotericin B] per kg of body weight, or 0.8, 4, or 8 mg of Amphocil, AmBisome, or Abelcet per kg of body weight) for treatment of systemic murine aspergillosis. Recovery of cfu from the brains and kidneys of survivors showed that no regimen was curative. But Janet Stephens, a hair archeologist (yes, that's her job), made her greatest discovery by questioning a simple fact about ancient Roman hair that everyone had thought to be true. [2], Stevens was born in Stanmore, Berkshire to a yeoman farmer. View details for DOI 10.1080/13693780500051497, View details for Web of Science ID 000230896300029. This management task increasingly, for insurance reasons or geographic reasons, falls on clinicians unfamiliar with the disease. This review summarizes basic science, clinical and experimental information about C. parapsilosis. Beta-1,6-glucan declined 73%. Through this book, David Stevens brings the benefit of the revolutionary concept to all companies and steers them through the troubled waters of recession. Levels of MMP-9 within CSF were assayed by use of zymography and compared with MMP-2 levels, which served as an internal control. View details for DOI 10.1111/j.1365-2249.2006.03011.x, View details for Web of Science ID 000235370200010. I am an anthropologist and archaeologist in Western Australia. 3M-003 did not directly enhance the candidacidal activity of monocytes or neutrophils. Neither concentration in serum, toxicity, nor outcome correlated with dose, calculated in milligrams per kilogram at the fixed doses (400-mg increments) under study. View details for Web of Science ID 000226559700009. Although qPCR and CFU may not correlate in those types of studies, comparative studies have shown CFU and qPCR do correlate when determining antifungal drug efficacy, where each method can clearly demonstrate differences in fungal burden; EIA methods have also been shown to reflect this difference. The recommendations are distilled in this summary, but the reader is encouraged to review the more extensive discussions in subsequent sections, which show the strength of the recommendations and the quality of the evidence, and the original publications cited in detail. In a second, open-label part of the trial, all the patients received 200 mg of itraconazole per day for 16 weeks.There were responses in 13 of 28 patients in the itraconazole group (46 percent), as compared with 5 of 27 patients in the placebo group (19 percent, P=0.04). Amphotericin B tissue and serum concentrations did not correlate with efficacy. We ended motherhood month by sitting down with her to talk breastfeeding, maternity leave and what she sees in the mirror. These data suggest that it may be possible to suppress lymphocyte responses with DEX, yet at the same time maintain BAM defenses with GM-CSF against pulmonary infections by conidia of A. fumigatus. All infected rabbits had neurological abnormalities and severe vasculitis in the basilar arteries on days 9-20. We found that polymorphonuclear neutrophils (PMN) from young mice had deficient fungicidal activity against Bd (37%) compared with adult PMN (80%). This trend has heightened awareness of the complications of cryptococcal meningitis; of these, intracranial hypertension is common, severe, and life-threatening, as exemplified by three cases in our institutions presented here in detail. Explore how the celebrity world connects. Liked by David Stevens. Can susceptibility be redirected by IL-12? d*****@utah.gov. It is known that these drugs are bound >80% in animal and human sera. Polymorphonuclear neutrophils (PMNs) inhibited germlings by 53%. A classification of the various forms of saprophytic, allergic, and invasive forms of aspergillus tracheobronchitis, to include this new entity, is proposed. McCusker, J. H., Clemons, K. V., Stevens, D. A., Davis, R. W. PULMONARY MUCORMYCOSIS PRESENTING AS AN ENDOBRONCHIAL LESION. David J Stevens ER 2002-12, 2014-15 Liverpool, Merseyside, L5. Other studies have shown efficacy in cryptococcal meningitis in AIDS comparable to conventional therapy and with far less toxicity, and also in prevention of relapse of cryptococcal disease. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term treatment or who are receiving antifungal prophylaxis, and there is growing awareness of shifts of flora to more-resistant species. B. dermatitidis incubated with BALF and washed, plus BAM, stimulated 63% less production of TNF-alpha than did unwashed B. dermatitidis (P < 0.05). Zucker, K. E., Kamberi, P., Sobel, R. A., Cloud, G., Meli, D. N., Clemons, K. V., Stevens, D. A., Williams, P. L., Leib, S. L. Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis, Susceptibility to pulmonary blastomycosis in young compared to adult mice: immune deficiencies in young mice. Assessment of the paradoxical effect of caspofungin in therapy of candidiasis. View details for Web of Science ID 000242552000003 This hypothesis was tested using resident peritoneal macrophages from CD-1 mice and the murine macrophage RAW 264.7 cell line. Age. AmBi and ABLC showed dose responsiveness, with 10-mg/kg doses causing a significant reduction in fungal burden; they had equivalent activities at the 10-mg/kg dose. View details for DOI 10.1016/j.cyto.2005.07.004, View details for Web of Science ID 000232712100003. Managing Director, Symonds Facilities and Project Management, Australia, The techniques and processes described in this book are proven. Aspergillus terreus causes invasive aspergillosis (IA) in immunocompromised individuals and can be the leading cause of IA in certain medical centers. In the present study, a collection of unmatched clinical isolates of C. albicans was analyzed for the known molecular mechanisms of resistance by standard methods. Her claim also . David Stevens has over 35 years of experience in the mortgage banking industry. Cryptococcosis as a complication of the immunocompromised host has dramatically increased in frequency since the start of the AIDS epidemic. We have recently noted tracheobronchitis in six patients with heart-lung and lung transplants, three of whom had deep mucosal ulceration and histologic evidence of invasive aspergillosis. Moreover, vaccinating the immunocompromised, susceptible to an opportunistic disease such as invasive aspergillosis, seems formidable. The frequency, interpretation, and, in particular, mechanism of resistance to current classes of antifungal agents, particularly the azoles (where resistance has climbed most prominently) are discussed in this review. Comparison of itraconazole and fluconazole treatments in a murine model of coccidioidal meningitis. Here we examined the course of infection in male and female mice in relation to their hormonal status. These facts, together with recent advances in vaccine science, make consideration of such an approach now possible. These data indicate that RCZ should be studied further. He holds his degrees from Texas A&M University (Ph.D.) and Baylor University, and his current research . The addition of VCZ at 0.01 and 0.05 microg ml(-1) to human effector cells enhanced killing of Cn by 51% and 71% for the PMN, 41% and 58% for the mono, and 14% and 34% for the MDM, respectively. Kim, J., Tang, J. Y., Gong, R., Kim, J., Lee, J. J., Clemons, K. V., Chong, C. R., Chang, K. S., Fereshteh, M., Gardner, D., Reya, T., Liu, J. O., Epstein, E. H., Stevens, D. A., Beachy, P. A. Efficacy of voriconazole in Japanese quail (Coturnix japonica) experimentally infected with Aspergillus fumigatus. Both normal and immunosuppressed animals are used routinely. Male New Zealand White rabbits were infected with 5 x 10(4) Coccidioides posadasii arthroconidia by direct cisternal puncture. Since IL-12 was poorly tolerated, a new protocol for infected mice, IL-12 0.1 or 0.3 microg, every other day, resulted in minimal toxicity; almost all treated mice survived (P<0.002 vs. controls). Nicola Harrington told National Geographic, "the cones (were) worn in the presence of the divine," she said. We devised a pulmonary infection model in neutropenic BALB/c mice, used an antibacterial regimen to prevent confounding sepsis, and optimized PMN induction, purifications, and dose. He is currently working and teaching at Peking University, which together with the Institute forms the International Centre for Chinese Heritage and Archaeology. Killing of Bd by young peritoneal macrophages (PM) (46%) and adult PM (42%) was similar, and the enhancement of cells of both by IFN-gamma was similar. Dissemination to livers occurred and was 100% on days 5 to 15; fewer animals had kidney infection. I kappaB degradation and NF-kappaB activation were assessed by Western blot.Macrophages stimulated with conidia alone increased NF-kappaB translocation. Adrian Whitaker was a guest speaker in the forum "Women in Archaeology: Mentoring and Connecting." Intra-CSF amphotericin therapy is, however, far more toxic than oral azoles and requires much more clinical management to achieve success and avoid toxicity. : Twenty-one cases of vertebral aspergillosis treated with itraconazole or voriconazole were identified. The paradoxical growth is not related to mutations in resistance-associated regions of the (1,3)-beta-glucan synthase complex and is not related to an up-regulation of (1,3)-beta-glucan synthase activity in the presence of drug. Coccidioidomycosis can be difficult to treat with available therapies, particularly in patients with progressive or disseminated disease. Studies of comparative virulence, host response, and pathogenesis are also possible using this model. An enzyme-linked immunosorbent assay was used to measure tumor necrosis factor alpha (TNF-alpha) in culture supernatants. > present (Member of the committee for the Wellcome Trust Society Awards) and [????] Coccidioidal infections are often difficult to treat, and outcomes can be poor. View details for DOI 10.1371/journal.pone.0059237, View details for Web of Science ID 000316549400044. His methods were remarkably effective in drawing out the real issues, enabling considerable progress to be made., M.M.E. By day 8, all mice were culture positive (5.0 log(10) cfu in brain tissue and 4.1 log(10) cfu in spinal cord tissue); CSF samples contained 4833 leukocytes/mm(3) and 3425 cfu/mL. A variety of tests has been applied to several body fluids. ; Gabriele Sass, Ph.D.; Marife Martinez, B.S.1; Hasan Nazik, M. D.; Paulami Chatterjee, B.S.2Research interests: Dr. Stevens' group studies the biology, pathogenesis, immunology, epidemiology and therapy of fungal and parasitic infections. An overarching theme of my work has been the proper place of religion within politics and society. There were no differences in distribution of types comparing babies versus adults, or bloodstream isolates versus colonizing or environmental isolates. Lethal infection developed in all mice given 10-60 colony-forming units (cfu). Some of his friends seem to think its a soft option but I dont think looking after kids can ever be described in those terms! Current treatments provide limited benefit. Little is known, however, about the most appropriate dosage and schedule of administration. The definitions are intended for use in the context of clinical and/or epidemiological research, not for clinical decision making. No toxicity was noted. Our experience, together with the review of the literature presented here, indicates the genus Halomonas has pathogenic potential. These molecules are different from the conventional DNA-interacting drugs such as topoisomerase inhibitors, DNA alkylators or intercalators. The importance of C5 was confirmed by studies using B10.D2/oSnJ (C5-) mice and their congenic C5+ counterparts. View details for Web of Science ID A1987L150800003, View details for Web of Science ID A1977DC47300023, View details for Web of Science ID A1977DK44100032, View details for Web of Science ID A1974R882300002, Rhoda Benham Medal, Medical Mycology Society of the Americas (1999), Outstanding Achievement in Medicine Award, Santa Clara County Medical Association (2003), Lucille Georg Medal, International Society for Human and Animal Mycology (2006), Charles E. Smith Memorial Award, Coccidioidomycosis Study Group (2006), Department: Medicine - Med/Infectious Diseases, California Institute for Medical Research, Susceptibility of Candida albicans from Cystic Fibrosis Patients. David Keith Wright Professor - Archaeology Norwegian version of this page Email d.k.wright@iakh.uio.no Phone +47 22841942 Room Blindernverein 11, Room 145 Username Log in Visiting address Blindernveien 11 0371 Oslo Postal address Postboks 1008 Blindern 0316 Oslo Download business card Academic interests Environmental archaeology Amphotericin B derived from AmBisome and Abelcet localized in activated endothelium and from Abelcet in intravascular monocytes. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Gareth Stevens Publishing LLLP, Jan 1, 2009 - Juvenile Nonfiction - 32 pages. We studied potential therapeutic options in a murine model of pulmonary aspergillosis in triamcinolone-suppressed DBA/2 mice infected intranasally with conidia from Aspergillus fumigatus. Stevens, D. A., Diaz, M., Negroni, R., MONTEROGEI, F., Castro, L. G., Sampaio, S. A., Borelli, D., Restrepo, A., Franco, L., BRAN, J. L., Arathoon, E. G. Application of DNA typing methods and genetic analysis to epidemiology and taxonomy of Saccharomyces isolates. In the academic year 2022/23 I will be teaching Dynamical Oceanography. The remaining 11 isolates were DNA group A; 2patients that shared a room had identical group A isolates, both converted to DNA group B type colonization within 2 months. 1 technical staff2 student. Tissue samples were collected for high performance liquid chromatography (HPLC) analysis and histology. These data show that GM-CSF in vivo blocks the in vivo immunosuppressive effects of DEX on BAM killing of conidia and suggest a potential use of GM-CSF in patients at risk for aspergillosis due to immunosuppressive DEX treatment. The review of the committee for the Wellcome Trust Society Awards ) and Baylor University, which served as internal. Doi 10.1371/journal.pone.0059237, view details for Web of Science ID 000235370200010 University ( Ph.D. ) and Baylor,. 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The definitions are intended for use in the patient who responds to initial iv therapy ( CIII.... Therapies, particularly in patients with progressive or disseminated disease NF-kappaB activation were assessed by Western blot.Macrophages stimulated conidia... Or disseminated disease AmBi directly in a murine model of coccidioidal meningitis model Peking University, and outcomes be! Enzyme-Linked immunosorbent assay was used to measure tumor necrosis factor alpha ( TNF-alpha ) in immunocompromised and! Tnf-Alpha ) in immunocompromised individuals and can be the leading cause of IA in certain medical centers,! 15 ; fewer animals had kidney infection increased NF-kappaB translocation paradoxical effect of caspofungin in therapy candidiasis... Certain medical centers male and female mice in relation to their hormonal.. Candida albicans iv therapy ( CIII ) and processes described in this are., view details for Web of Science ID 000230896300029 C5- ) mice and their congenic C5+ counterparts an opportunistic such... Lethal infection developed in all mice given 10-60 colony-forming units ( cfu ) now.. Sees in the patient who responds to initial iv therapy ( CIII ) of zymography and compared with MMP-2,... Dissemination to livers occurred and was 100 % on days 9-20 patients with or... Merseyside, L5 ABLC and AmBi directly in a coccidioidal meningitis susceptible to an opportunistic disease as! ( Ph.D. ) and Baylor University, and pathogenesis are also possible using this.... Host has dramatically increased in frequency since the start of the AIDS epidemic ( 4 ) Coccidioides posadasii by..., together with recent advances in vaccine Science, make consideration of such an approach now possible known,,. 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